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Pyridoxal 5' phosphate (P5P) is an active metabolite and predominant circulating form of pyridoxine (vitamin B6 ). P5P is a cofactor for more than 100 enzymes. It is involved in the synthesis of neurotransmitters and works with folate and vitamin B12 in the metabolism of homocysteine and the formation of red blood cells.1 It is also required for enzymes that metabolize carbohydrates, fats,and proteins. If a person has certain genetic deletions such as MTHFR deletion they may not be able to change the synthetic form of pyroxidine (Vitamin B6) to the active form. P5p is the active form of vitamin B6
In 1965, two Russian physicians , M.G. Blumena and T.L. Belakova, published a report showing improvement in the speech in developmentally delayed children when given dimethyglycine(DMG). In Russia it is considered a nootropic drug and used extensively with children who have developmental delay especially inability to talk. It appears that DMG like it’s closely related cousin TMG acts as a key intermediary in the biological pathway that supplies the body with methyl groups; it is a methyl donator.
Bernard Rimland PhD, founder of the Autism Society of America and the Autism Research Institute, pioneered the use of B vitamins in the 1960s for his own son, who was affected by autism.
The original Super Nu-Thera was formulated by Kirkman at the urgent request of Dr. Bernard Rimland, who wanted a nutritional supplement with high vitamin B6 and magnesium content that tasted good so children would take the product. This form includes the Active form of B6.
Methyltetrahydrofolate (5-MTHF) is the most biologically active form of the B-vitamin folic acid, also known generically as folate. 5-MTHF functions, in concert with vitamin B12, as a methyl-group donor involved in the conversion of the amino acid homocysteine to methionine. Methyl (CH3) group donation is vital to many bodily processes, including serotonin, melatonin, and DNA synthesis. Therapeutically, 5-MTHF is instrumental in reducing homocysteine levels, preventing neural tube defects, and improving vascular endothelial function. Research on folate supplementation suggests it plays a key role in preventing cervical dysplasia and protecting against neoplasia in ulcerative colitis. Folate also shows promise as part of a nutritional protocol to treat vitiligo, and may reduce inflammation of the gingiva. Furthermore, certain neurological, cognitive, and psychiatric presentations may be secondary to B\folate deficiency. Such presentations include depression, peripheral neuropathy, myelopathy, restless legs syndrome, insomnia, dementia, forgetfulness, irritability, endogenous depression, organic psychosis, and schizophrenia-like syndromes. 5-MTHF supplementation may be a more favorable method of folate repletion. A small amount of children may have muscle pain or irritability with the supplement and in this case Folinic Acid may be more appropriate.
Zinc is present in every cell in the body, is a component of over 200 enzymes, and is involved in more enzymatic reactions than any other mineral constituent in mammals. Zinc is essential for normal skin, vision, smell, taste, reproduction, brain development, protein synthesis and wound healing. It is also one of the most important factors in a healthy immune system. Zinc is involved in just about every aspect of immunity, including the immune enhancing “T” cells,that are necessary for immune response.
Zinc levels in the body may be lowered for many reasons
A study published in the Archives of General Psychiatry found that “reduced GABA concentration in ADHD in concordant with recently reported deficits in short intracortical inhibition in ADHD and suggests a GABAergic deficit in ADHD.” (Edden, Crocetti, Zhu, Gilbert, & Mostofsky, 2012) Despite the relationship between low GABA concentration and ADHD diagnoses, the efficacy of GABA supplements has not been widely studied. However, GABA supplements have amassed quite the reputation for being a holistic component of treating ADHD. One study at the Kyorin University Medical School in Japan conducted a study that indicated GABA potentially helps students with ADHD.
Biofilms are an emerging area of treatment for autistic childrenand indeed for many other types of illness
The biofilm helps the bacteria survive in the gut and protects them from the body’s immune system. Bacteria in the biofilm evade the immune system by not displaying the protein that says “I am a foreign invader” and without this the immune system doesn’t even see the threat to your child’s health.
- Biofilm Defense contains a combination of unique enzymes exclusively formulated by Kirkman scientists that can dissolve the sugar and fibrin components of biofilms.*
- SUPPORTS MICROBIOME BALANCE: Biofilm is a slimy substance that protects unhealthy microorganisms from the immune system and allows them to thrive, thus hindering the immune system from functioning optimally.
- SAFE FOR DAILY USE: Formulated for adults and children 4 years or older. Take one capsule daily or as directed by a physician.*
Folinic acid is most appropriate for those who have side effects with MTHF such as increased irritability or muscle aches.
Dr Frye, a fellow Arizona pediatric neurologist, found improvement in verbal communication in children with autism as measured by a ability-appropriate standardized instrument, was significantly greater in participants receiving folinic acid as compared with those receiving placebo.
to-large effect size (Cohen’s d=0.70)
Selenium is a trace mineral that is is part of several enzymes in energy metabolism, and in defenses against free radical damage and inflammation. Its role in the treatment of autism is not well studied, however, children with ASD often have diets that are relatively deficient in many trace minerals, including selenium. Some studies suggest that consuming plenty of selenium has positive antiviral effects, and also reduces the risk of heart disease, cancer, infertility, cognitive decline, autoimmune and thyroid diseases.
Kirkman Immuno-Aid Advanced Formula provides powerful support for the immune system. This "advanced" formula contains elderberry, a strong immune system supporter
Kirkman Mushroom Mental Clarity & Focus contains a blend of 4 superfood mushrooms and 6 other premium ingredients to enhance cognitive support, maintain mental alertness, clarity, focus, and memory without caffeine.
SMART MUSHROOM BLEND: Formulated with choice mushrooms: Reishi Mushroom, Cordyceps Sinensis, and Lion's Mane (hericium erinaceus) in recognition of their ability to support productivity, general wellness, and vitality*
SAFE FOR DAILY USE: Take one capsule twice daily or as directed by your physician.*
Methyl donors can help the body produce chemicals that can maintain serotonin levels in the body. TMG is a more active "methyl donor" than DMG because it has an additional methyl group in its chemical structure.
Buffered vitamin C is created when a mineral salt is added to ascorbic acid. This results in a substance that resists changes in pH, providing a better formulation choice for those with sensitive stomachs.
Monolaurin is a derived from lauric acid, a component of both coconut fat and breast milk which has antibacterial and ant fungal properties. This is a very beneficial supplement for high yeast levels.
16. Saccharomyces Boulardi-intestinal bacteria support .
Saccharomyces boulardii is a yeast, which is a type of fungus.
Saccharomyces boulardii is used for treating and preventing diarrhea, including infectious types such as rotaviral diarrhea in children, diarrhea caused by gastrointestinal (GI) take-over (overgrowth) by “bad” bacteria (especially Clostridium) in adults, traveler's diarrhea, and diarrhea associated with tube feedings. It is also used to prevent and treat diarrhea caused by the use of antibiotics.
Saccharomyces boulardii is also used for general digestion problems, irritable bowel syndrome (IBS), inflammatory bowel syndrome (IBD, Crohn's disease, ulcerative colitis), Lyme disease, a bowel disorder called relapsing Clostridium difficile colitis, and bacterial overgrowth in short bowel syndrome.
Some people use Saccharomyces boulardii for lactose intolerance, urinary tract infections (UTIs), vaginal yeast infections, high cholesterol levels, hives, fever blisters, canker sores, and teen-age acne.
Kirkman’s Yeast-Aid™ is a proprietary product formulated to support the immune system and control yeast levels in the body. Yeast-Aid™ was developed by working closely with several physicians and with the guidance of the late Dr. William Crook, an expert in yeast issues. It is intended that this supplement only be used if recommended by a physician.
GO BEYOND PROBIOTICS: Provides digestive and immune with a unique probiotic blend derived from choice mushrooms
UNIQUE MUSHROOM BLEND: Formulated with nine different mushrooms chosen for their specific benefits. Includes Agaricus Blazei Murill, LactoSpore, Cordyceps Sinensis, Lion's Mane, Maitake, Reishi, Shiitake, Turkey Tail Mushroom, and Chaga Mushroom
Inositol supports Nervous System Health and the brain and a healthy central nervous system function. As a result, inositol may support healthy behavior.*
Some research suggests that L carnosine may help to improvevocabulary, language comprehension, communication, socialization, object recognition, awareness of surroundings, fine motor skills, and auditory processing in autistic children.
Recent evidence shows that subjects diagnosed with an autism spectrum disorder (ASD) have significantly lower levels of glutathione than typically developing children. Glutathione helps remove and decrease toxins from the environment and food exposure.
Kirkman Carb Digest with Isogest aids in digesting carbohydrates. It is an exceptional product that provides a complete profile of disaccharidase enzymes present in the human body. It also contains Kirkman’s proprietary Isogest enzyme. This unique formulation may be useful to those on the Specific Carbohydrate Diet because slight infractions of the diet may be counteracted.
Epsom salts help with detoxification, increase magnesium in the body, aids in relieving constipation and brings about calmness and relaxation in children.
Lysine Immune is one-of-a-kind formulation that offers potent immune support, with a unique combination of nutrients designed to enhance immune function. Each capsule contains: * L-Lysine * Vitamin A from Beta Carotene * Vitamin B-6 from Pyridoxine HCI * Vitamin C from Mineral Ascorbate * Vitamin E from d-Alpha-Tocopheryl Succinate * Zinc from Zinc Oxide * Pyridoxal-5-Phosphate-Coenzymatic form of Vitamin B-6 * Bioflavonoids; Rutin and Hesperidin
Based on research studying high doses of CoQ10 studies show it can improve gastrointestinal problems (P = 0.004) and sleep disorders (P = 0.005) in children with autism with an increase in the CoQ10 of the serum. Research concluded that the serum concentration of CoQ10 and oxidative stress could be used as relevant biomarkers in helping the improvement of autism .
26. Kirkman - Cod Liver Oil with Vitamin A & D
In children with autism, inflammation is prevalent. Fish oils can aid beneficial reactions towards reducing brain inflammation, impacting our neurotransmitters, concentration, mood, sleep, and irritability.
27. Kirkman - Pro-Bio Gold - 120 Capsules - Supports Immune Health - Digestive Aid with Probiotics -
SUPPORTS GUT HEALTH: Kirkman Pro-Bio Gold provides comprehensive digestion support for most food groups with a total probiotic potency of 21 billion CFUs.
A comprehensive formula designed to support optimal methylation and help maintain healthy homocysteine levels already within the normal range. It features five key nutrients that are involved in homocysteine metabolism: folate as calcium folinate and Quatrefolic for increased bioactivity; trimethylglycine; and vitamins B12, B6, and B2. These five nutrients, provided in activated forms, support enhanced methylation and overall cardiovascular health.
A highly effective and highly absorbable form of vitamin C.
Liposomal Vitamin D3 with K2. D3 must have K2 to work
This Tumeric supplement is highly absorbable and the addition of pipeline from black pepper increases absorption in the blood by as much as 2000%.
Binders are natural adsorbents like clays, charcoal, and zeolite. You want these binders to be available to bind with toxins in the digestive tract. The binders will then help safely remove the toxins from the body, keeping the toxins from being reabsorbed back into the bloodstream.
Binders can help the body eliminate a variety of toxins:
Heavy Metals, Chemicals, and Plastics
Mercury, Aluminum, Lead, Chemicals, Radiation, Herbicides and Pesticides , Plastics, VOCs (volatile organic compounds)
BIOCIDIN® LIQUID BENEFITS
Supports gut health by addressing unwanted organisms
Dismantles biofilms
Selectively enhances beneficial organisms
Immunomodulatory activity
May improve regularity and reduce bloating and gas
Helps improve vitality and mental clarity
Supports healthy mobility and body comfort
The oral microbiome is a collection of microorganisms in the mouth, both harmful and beneficial. What grows in the mouth is swallowed and may go on to grow in the gut.
Research using phase-contrast microscopy shows how Dentalcidin® LS utilizes liposomal technology to clear unwanted microbes in dental plaque.
This effectively supports oral microbiome balance and, ultimately, whole-body health.
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The Whole House Air Purifier by Triad Aer V3 Air Purification System thoroughly improves indoor air quality up to 3,000 sq ft. With 5-way advanced filtration technology, the energy-efficient Triad Aer V3 is best for removing dust, mold, smoke, odors, allergens, viruses and more from the air.
- Electrostatic Filtration
- Needlepoint Ionization
- Advanced Photocatalytic Oxidation
- Pulse Ionization
- Scalable Air Purification
- Purifies Air Up to 3,000 sq ft
- Energy Efficient (45-watts)
38. Triad Aer Shield Personal Air Purifier
42. Juva Cleanse Essential Oil 15ml by Young Living Essential Oil
44 Star Foods - Grassfed Ghee (Grassfed Biodynamic)
45. UTK 24''x 70'' Large Far Infrared Heating Pad,๐ ๐ฎ๐ฅ๐ฅ ๐๐จ๐๐ฒ ๐๐๐๐ญ๐ข๐ง๐ ๐๐๐,Jade Heating Pad with 429 Individual Nature Gemstones,Memory Function, Auto-Off, Travel Bag Included
48 Samsali Ginger Foot Pads
49 Quicksilver Scientific Ultra Binder - Multi Toxin Binder with Bentonite Clay Powder, Zeolite Detox & Charcoal - Supplement
51 Pendulum Akkermansia for Gut Health | The ONLY Brand with Live Akkermansia Muciniphila
Lack of or low levels of Akkermansia in the gut is associated with a thin mucus layer, i.e., weakened gut barrier function, and has also been associated with obesity, diabetes, inflammation, and metabolic disorders.
Unfortunately, Akkermansia is not found in food. However, it does feed on fiber. While there are many types of fiber-containing foods, research shows that the ones that best support Akkermansia growth are polyphenol-rich foods and prebiotic fibers. Research by the NIH reported low levels of Akkermansia were found in the body of children with moderate to severe autism.
52 OMI Ring - Magnetic Field Therapy Ring for Natural Healing
Thousands of studies have been done pointing to the beneficial effects of low level pulsed magnetic fields. PEMF therapy can also help children with autism by improving circulation. Studies show that the improvement of blood flow in the body and the brain is one of the most important factors to help individuals communicate better, and complete cognitive tasks more quickly and more easily. By enhancing blood flow, children with autism can link their thoughts and speech with greater ease, thus being able to communicate better and think more clearly.
53 Hooga Grounding Mat for Sleep, Energy, Pain Relief, Inflammation, Balance
Earthing is not a cure for autism, but some researchers describe a calming effects in autism,, improvement in sleep patterns, as well as better speech and socializing. Reducing the impact of autism on a child in this natural and simple way simultaneously lessens the stress level in the whole family. Earthing may open a door of hope with those children who have EMF sensitivity or electrostatic imbalances.
Scientifically known as Bacopa monnieri, Brahmi is an important herb that delays the process of forgetting and improves memory. Not only does Brahmi improve memory, but research suggests that it also increases the grasping power, intellect and speech and also corrects the abnormality of emotions, personality and mood of an autistic individual. It also helps in performing complex tasks such as comprehension, reasoning and learning.
55 HawaiiPharm Rhodiola Liquid Extract, Organic Rhodiola
Helpful for managing the symptoms of ADHD, rhodiola rosea improves focus and supports the neurological system that produces serotonin and dopamine, which are two important antidepressant brain neurotransmitters
- MTHFR mutations cause a reduction in or inactivity of the MTHFR enzyme. This enzyme converts folate into its more active form and processes the amino acid homocysteine into methionine.
- MTHFR mutations can lead to vitamin B12, B6, and folate deficiencies and increases homocysteine levels in the body.
- People with MTHFR mutation have an increased risk of developing mental health issues, fatigue, cardiovascular problems, migraines, certain types of cancer, and neural tube defects in fetuses.
57 LIFESTACKS Nootropic Vanilla MCT Oil Powder
58. High quality MCT oil for ketogenic diet
59. Genius Consciousness, Super Nootropic Brain Supplement Powder, Watermelon
60. Bestqool Red Light Therapy Device, Four Wavelengths Full Body Near Infrared Light
61.Neo40 Professional - Nitric Oxide Booster with Methylfolate
I
Neo 40 promotes
Artery dilation for healthy blood flow
Healthy blood pressure levels
Cardiovascular and heart health
Increased circulation throughout the body
Healthy brain arterial function
Healthy endothelium function
A direct connection between levels of nitric oxide in the brain and autism has been established for the first time in a new study. The breakthrough findings, from a team led by Dr Haitham Amal at the Hebrew University of Jerusalem, offer an insight into a previously undiscovered mechanism underlying the development of autism, which affects around one in 36 children in the US alone.
The nitric oxide pathway has been \pivotal in exploring neurodevelopmental disorders. Pathogenesis of autism spectrum disorders (ASD) is also suspected to involve a number of biological cascades triggered by nitric oxide-induced neurotoxicity. The excessive nitric oxide levels caused by varied toxicants leads to the formation of reactive nitrogenous species along with ROS leading to mitochondrial dysfunction, oxidative stress, neuroinflammation, and altered NOS expression responsible for worsening of behavioral complications.
62. Probonix Probiotics for Babies, Organic, Non-GMO Liquid Probiotic Drops with 8 Live
63. JustThrive Spore Probiotic
Spore-based probiotics or SBOs ( Soil-based organisms) are the names given to these tiny organisms found naturally occurring in the soil. These SBOs can survive in harsh conditions and have a natural resistance to stomach acid, making spore-based probiotic a perfect choice when dealing with our digestive tract. Research has also found that these organisms can actually penetrate the blood brain barrier and enter the central nervous system through the deep lymphatic system.
We strongly advise that persons needing specific medical advice seek the services of a duly licensed professional. Every child is unique, and to attempt to address complex medical issues without a trained and experienced expert is akin to a lay person attempting to perform surgery without any training. Doing either would risk serious (and in some cases could have irreversible consequences). The Hope Center was one of the first Centers to provide provides Virtual Telehealth consultations for patients across the globe ---just contact us through our contact information below.